Morpholine → 1-[3-Chloro-5-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-2-methyl-6-(2-morpholin-4-yl-ethoxy)-phenyl]-ethanone

Participants

Reaction Steps

Example 8a (100 mg, 0.21 mmol) was reacted with morpholine (6.0 eq.) as described under General Procedure G. The title compound was afforded as an oil (72 mg, 71%). 1H NMR (300 MHz, CDCl3) δ 7.18-7.13 (m, 2H), 6.99-6.89 (m, 2H), 4.05 (t, J=5.7 Hz, 2H), 3.94 (t, J=6.7 Hz, 2H), 3.82 (s, 3H), 3.70-3.67 (m, 4H), 3.02-2.95 (m, 1H), 2.59 (t, J=5.7 Hz, 2H), 2.49 (s, 3H), 2.47-2.44 (m, 4H), 2.17 (s, 3H), 2.03-1.96 (m, 2H), 1.28 (d, J=7.0 Hz, 3H). MS (ES+) m/z 493.9 (M+H+).

Provenance & Evidence