Hydrochloric Acid → HCID 67009989, compound

Participants

Reaction Conditions

Reaction Steps

1.8 g (6.0 mmol) of ethyl 1-(5-methyl-3-isoxazolyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate was dissolved in acetic acid (50 mL), and 6 N hydrochloric acid (10 mL) was added to this solution at room temperature. The resulting mixture was stirred for 5 hours at 60° C. The solvent was distilled off from the reaction mixture, and the residue was dissolved in toluene. The solvent was distilled off under reduced pressure, and thus 1.7 g of the title compound was obtained as colorless crystals (yield: quantitative).

Provenance & Evidence