(S)-4,4,5,5-tetramethyl-2-(4-(tetrahydrofuran-3-yloxy)phenyl)-1,3,2-dioxaborolane → HCID 178461302, compound

HRID 2194561Notes

Reaction equation

HRID 2194561 reaction equation
[O:1]1[CH2:5][CH2:4][C@@H:3]([O:6][C:7]2[C:12](Br)=[CH:11][N:10]=[C:9]([NH:14][C@H:15]3[CH2:20][CH2:19][C@@H:18]([CH3:21])[CH2:17][CH2:16]3)[N:8]=2)[CH2:2]1.[O:22]1[CH2:26][CH2:25][C@H:24]([O:27][C:28]2[CH:33]=[CH:32][C:31](B3OC(C)(C)C(C)(C)O3)=[CH:30][CH:29]=2)[CH2:23]1>>[O:1]1[CH2:5][CH2:4][C@@H:3]([O:6][C:7]2[C:12]([C:31]3[CH:32]=[CH:33][C:28]([O:27][C@H:24]4[CH2:25][CH2:26][O:22][CH2:23]4)=[CH:29][CH:30]=3)=[CH:11][N:10]=[C:9]([NH:14][C@H:15]3[CH2:20][CH2:19][C@@H:18]([CH3:21])[CH2:17][CH2:16]3)[N:8]=2)[CH2:2]1

Participants

3

Reactant 2

HCID 71108019(S)-4,4,5,5-tetramethyl-2-(4-(tetrahydrofuran-3-yloxy)phenyl)-1,3,2-dioxaborolaneHCID 178461298HCID 178461298, compound

Product 1

HCID 178461302HCID 178461302, compound

Procedure

Using the procedure of Example 1, Step 3, 4-((R)-tetrahydrofuran-3-yloxy)-5-bromo-N-(cis-4-methylcyclohexyl)pyrimidin-2-amine was reacted with 2-(4-((S)-tetrahydrofuran-3-yloxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane to provide the title compound as a free base.

Sources & evidence

ORD record
ord-4d1eb001ca32493a90a461c5e34dd243
Source dataset
uspto-grants-2012_12
Patent number
US08334292B1

Reaction notes

Loading…