反应详情

Using the procedure of Example 1 Step 2, (R)-tert-butyl 3-((5-bromo-2-chloropyrimidin-4-yloxy)methyl)pyrrolidine-1-carboxylate was reacted with cis-4-methylcyclohexanamine to provide the title compound at 55% yield. 1H NMR (CDCl3, 400 MHz) δ 8.06 (s, 1H), 5.13 (sb, 1H), 4.28 (m, 2H), 3.96 (m, 1H), 3.60-3.15 (m, 4H), 2.66 (m, 1H), 2.02 (m, 1H), 1.77-1.58 (m, 7H), 1.44 (s, 9H), 1.28-1.16 (m, 3H), 0.91 (d, 3H); MS (ESI) m/z: Calc: 544.2 (M+). Found. 545.2 (M+1).