Methyl chloroformate → HCID 178501927, compound

Participants

Reaction Steps

Using the procedure of Example 1 Step 5, 4-(((R)-pyrrolidin-3-yl)methoxy)-N-(cis-4-methylcyclohexyl)-5-(4-morpholinophenyl)pyrimidin-2-amine with methyl chloroformate to provide the title compound. 1H NMR (CDCl3, 400 MHz) δ 8.08 (s, 1H), 7.38 (d, 2H), 6.94 (d, 2H), 5.22 (sb, 1H), 4.31 (d, 2H), 4.07 (m, 1H), 3.88 (m, 4H), 3.70 (s, 3H), 3.72-3.36 (m, 4H), 2.68 (m, 1H), 2.03 (m, 2H), 1.87-1.52 (m, 6H), 1.25 (m, 3H), 0.95 (d, 3H); MS (ESI) m/z: Found: 510.3 (M+1). Calc. 509.3 (M+).

Provenance & Evidence