HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 8-chloro-3,4-dihydro-2H-1,5-benzodioxepin-6-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | methyl 8-chloro-3,4-dihydro-2H-1,5-benzodioxepin-6-carboxylate | HCID 18613659 | — |
| Solvent | Water | HCID 962 | — |
| Product | 8-chloro-3,4-dihydro-2H-1,5-benzodioxepin-6-carboxylic acid | HCID 11229938 | 84% |
Reaction Steps
A mixture of intermediate (5) (0.25 mol) and KOH (1 mol) in water (650 ml) was stirred and refluxed for 2 hours. The reaction mixture was cooled, acidified with HCl, the resulting precipitate was filtered off, washed with water, and dried, yielding 48 g of 8-chloro-3,4-dihydro-2H-1,5-benzodioxepin-6-carboxylic acid (intermediate 6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08334304B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-7ae1fa3f09264b6bb8b4f2badd612227 |
| Source note | uspto-grants-2012_12 |