HCID 25121885, compound → HCID 178438004, compound

Participants

Reaction Steps

150 mg of [5-(3-methoxybenzyl)-1,3,4-oxadiazol-2-yl]-(3-vinyl-1H-indazol-5-yl)amine (as trifluoroacetic acid salt, prepared from “A43”) are hydrogenated at room temperature in 10 ml of methanol in the presence of 150 mg of Pd/C. The reaction mixture is filtered and evaporated. Purification by column chromatography on silica gel (eluent: heptane/EA) gives 50 mg of (3-ethyl-1H-indazol-5-yl)-[5-(3-methoxybenzyl)-1,3,4-oxadiazol-2-yl]amine (44%); MS-FAB (M+H+)=350.39; Rf (polar method): 1.836 min.;

Provenance & Evidence