HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2194635Generated: October 29, 2026
Trifluoroacetic acid → Ethyl 3-[2-(1-isopropylcarbamoyl-piperidin-4-yl)-ethoxy]-benzoate
https://huagongshe.com/reaction/2194635
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Isopropyl isocyanate | HCID 61277 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Ethyl 3-(2-piperidin-4-yl-ethoxy)-benzoate | HCID 56830235 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 3-[2-(1-isopropylcarbamoyl-piperidin-4-yl)-ethoxy]-benzoate | HCID 66929612 | — |
Reaction Steps
Ethyl 3-(2-piperidin-4-yl-ethoxy)-benzoate (1.0 g of the TFA salt, 2.6 mmol) was dissolved in DCM (10 ml), wereupon DIPEA (1.3 ml, 7.7 mmol) and isopropyl isocyanate (0.33 g, 3.8 mmol) was added. The reaction mixture was shaken overnight at 20° C. Silica gel (10 ml) was added, and the solvent removed in vacuo. Flash chromatography (EtOAc/heptan 35:65→55:45) provided 0.67 g of the title compound. LC-MS (m/z): 364 (M+2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08334305B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-4b0d84bceb20428db29ce1c8a4f24a5b |
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| Source note | uspto-grants-2012_12 |
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