HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-hydroxybenzoate → 3-{2-[1-(3-Hydroxy-2,2-dimethyl-propionyl)-piperidin-4-yl]-ethoxy}-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-hydroxybenzoate | HCID 24522 | — |
| Reactant | 1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine | HCID 854140 | — |
| Reactant | Ethyl 3-(2-piperidin-4-yl-ethoxy)-benzoate | HCID 56830235 | — |
| Product | 3-{2-[1-(3-Hydroxy-2,2-dimethyl-propionyl)-piperidin-4-yl]-ethoxy}-benzoic acid | HCID 68782049 | — |
Reaction Steps
Prepared from N-Boc-4-piperidine ethanol and ethyl 3-hydroxybenzoate, with the exception that ethyl 3-(2-piperidin-4-yl-ethoxy)-benzoate was converted to its corresponding carboxamide as described below before the final alkaline hydrolysis to give the title compound. LC-MS (m/z): 351 (M+2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08334305B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-68c66e7ccc4e485a9c38145e34e61507 |
| Source note | uspto-grants-2012_12 |