1,3-Dibromopropane → 1-{2-(3-Bromo-propoxy)-5-chloro-3-[3-(4-fluoro-phenyl)-butoxy]-4-methoxy-6-methyl-phenyl}-ethanone

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Reaction Steps

Example 7c (179 mg, 0.47 mmol) was reacted with 1,3-dibromopropane (10.0 eq.) as described under General Procedure F to afford the title compound (641 mg, quantitative yield) as a light yellow oil. 1H NMR (300 MHz, CDCl3) δ 7.19-7.15 (m, 2H), 7.01-6.95 (m, 2H), 4.10 (t, J=5.9 Hz, 2H), 3.94 (t, J=6.7 Hz, 2H), 3.84 (s, 3H), 3.49 (t, J=6.5 Hz, 2H), 2.99 (m, 1H), 2.46 (s, 3H), 2.17 (m, 5H), 2.07-1.99 (m, 2H), 1.30 (d, J=6.9 Hz, 3H). MS (ES+) m/z 503.0 (M+H+)

Provenance & Evidence