Water → HCID 57687714, compound

Participants

Reaction Conditions

Reaction Steps

A solution (30 mL) of ethyl 1-phenyl-2-(phenylthio)-1H-imidazole-4-carboxylate (1.17 g) in tetrahydrofuran was cooled to −70° C., a 1.5 mol/L solution (12 mL) of diisobutylaluminum hydride in toluene was added dropwise by small portions. The reaction mixture was stirred at 0° C. for 4 hr, water was added and the mixture was stirred for 30 min. Tetrahydrofuran was added to the obtained gel and the mixture was filtered. The filtrate was concentrated under reduced pressure. A mixed solution of ethyl acetate-diisopropyl ether (1:1) was added to the residue, and insoluble crystals were collected by filtration to give the title compound as pale-yellow crystals (yield 797 mg, yield 78%).

Provenance & Evidence