Water → HCID 86644404, compound

Participants

Reaction Steps

To a solution of 2-phenyl-1H-imidazole-4-carbaldehyde (700 mg) in dimethylformamide (30 mL) was added sodium hydride (60% in oil, 180 mg) at room temperature and the mixture was stirred for 30 min. 2-Chloropyrimidine (489 mg) was further added and the mixture was stirred for 15 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=4:1→2:3) to give the title compound as a yellow oil (yield 160 mg, yield 16%).

Provenance & Evidence