HCID 86644410, compound → HCID 86644411, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl ({5-[hydroxy(phenyl)methyl]-4-phenyl-2-thienyl}methyl)methylcarbamate (385 mg) in toluene (5 mL) was added manganese dioxide (1.1 g) and the mixture was stirred at 120° C. for 8 hr. The reaction mixture was cooled to room temperature, filtered through celite, and washed with ethyl acetate. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=9:1→4:1) to give the title compound as a pale-yellow oil (yield 236 mg, yield 62%).

Provenance & Evidence