Sodium Carbonate → HCID 86644413, 화합물

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A suspension of 4,5-dibromothiophene-2-carbaldehyde (2.0 g), (2-fluorophenyl)boronic acid (1.6 g), tetrakis(triphenylphosphine)palladium (0) (855 mg) and sodium carbonate (2.0 g) in 1,2-dimethoxyethane (32 mL) and water (8 mL) was stirred at 80° C. for 6 hr under a nitrogen atmosphere. The reaction mixture was cooled to room temperature, water was added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous sodium hydrogen carbonate solution, water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=99:1→9:1→17:3) to give the title compound as a colorless amorphous (yield 310 mg, yield 14%).

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