HCID 25254220, compound → HCID 25254525, compound

HRID 219470Notes

Reaction equation

HRID 219470 reaction equation
ClC1C(C)=C(C(=O)C)C(O)=C(OCCCC2C=CC(F)=CC=2)C=1OC.Cl[C:27]1[C:28]([CH3:58])=[C:29]([C:55](=[O:57])[CH3:56])[C:30]([O:46][CH2:47][CH2:48][N:49]2[CH2:54][CH2:53][O:52][CH2:51][CH2:50]2)=[C:31]([O:35][CH2:36][CH2:37][CH2:38][C:39]2[CH:44]=[CH:43][C:42](F)=[CH:41][CH:40]=2)[C:32]=1[O:33][CH3:34]>>[CH3:34][O:33][C:32]1[CH:27]=[C:28]([CH3:58])[C:29]([C:55](=[O:57])[CH3:56])=[C:30]([O:46][CH2:47][CH2:48][N:49]2[CH2:50][CH2:51][O:52][CH2:53][CH2:54]2)[C:31]=1[O:35][CH2:36][CH2:37][CH2:38][C:39]1[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=1

Participants

3

Reactant 2

HCID 25254220HCID 25254220, compoundHCID 59583493HCID 59583493, compound

Product 1

HCID 25254525HCID 25254525, compound

Procedure

Example 33b was prepared in a using a similar method as used in the conversion from 1d to 1f. 1H NMR (300 MHz, CDCl3) δ 7.30-7.15 (m, 5H), 6.47 (s, 1H), 4.12 (t, J=5.7 Hz, 2H), 4.01 (t, J=6.4 Hz, 2H), 3.82 (s, 3H), 3.69-3.66 (m, 4H), 2.81 (t, J=7.3 Hz, 2H), 2.62 (t, J=5.7 Hz, 2H), 2.52 (s, 3H), 2.47-2.44 (m, 4H), 2.20 (s, 3H), 2.09-2.00 (m, 2H). MS (ES+) m/z 428.0 (M+H+).

Workup

  1. customExample 33b was prepared in a using a similar method

Sources & evidence

ORD record
ord-9732b67e97584e76827a146aa2274c49
Source dataset
uspto-grants-2012_06
Patent number
US08202513B2

Reaction notes

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