Hydrogen chloride-ethyl acetate → HCID 86644420, compound

Participants

Reaction Steps

tert-Butyl({1-(2-chlorophenyl)-5-[(6-chloropyridin-3-yl)thio]-1H-pyrazol-3-yl}methyl)methylcarbamate (350 mg) was dissolved in ethyl acetate (3 mL) and methanol (2 mL), 4 mol/L hydrogen chloride-ethyl acetate solution (5 mL) was added and the mixture was stirred at room temperature for 3 hr. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from a mixed solvent of ethyl acetate and hexane, and recrystallized from a mixed solvent of ethyl acetate and ethanol to give the title compound as colorless crystals (yield 252 mg, 83%).

Provenance & Evidence