Hydrogen chloride-ethyl acetate → HCID 68411870, compound

Participants

Reaction Steps

tert-Butyl methyl({5-[methyl(phenyl)amino]-1-phenyl-1H-pyrazol-3-yl}methyl)carbamate (67 mg) was dissolved in ethyl acetate (1 mL) and methanol (0.5 mL), a 4 mol/L hydrogen chloride-ethyl acetate solution (2 mL) was added, and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, and the residue was crystallized from a mixed solvent of ethyl acetate and hexane, and recrystallized from a mixed solvent of ethyl acetate and ethanol to give the title compound as colorless crystals (yield 25 mg, yield 45%).

Provenance & Evidence