HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 219474Generated: October 25, 2026
Thiomorpholine → 1-[3-Chloro-4-methoxy-2-methyl-5-(3-phenyl-propoxy)-6-(2-thiomorpholin-4-yl-ethoxy)-phenyl]-ethanone
https://huagongshe.com/reaction/219474
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | 1-[2-(2-Bromo-ethoxy)-5-chloro-4-methoxy-6-methyl-3-(3-phenyl-propoxy)-phenyl]-ethanone | HCID 59583495 | — |
| Product | 1-[3-Chloro-4-methoxy-2-methyl-5-(3-phenyl-propoxy)-6-(2-thiomorpholin-4-yl-ethoxy)-phenyl]-ethanone | HCID 25254375 | 79% |
Reaction Steps
Example 34b (201 mg, 0.44 mmol) and thiomorpholine were reacted as described under the General Procedure B (except heated to 65° C.) and the crude was purified by flash chromatography (silica-gel, EtOAc/hexane 1:4) yielding the title compound (166 mg, 79%) as an oil. 1H NMR (300 MHz, CDCl3) δ 7.33-7.02 (m, 5H), 4.13-4.06 (m, 4H); 3.88 (s, 3H); 2.82 (dd, J=9.3, 7.5 Hz, 2H); 2.76-2.73 (m, 4H); 2.68-2.64 (m, 6H); 2.52 (s, 3H); 2.20 (s, 3H), 2.13-2.03 (m, 2H). MS (ES+) m/z 478 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08202513B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-4e045b7e43ac4e468c690edeaadca965 |
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| Source note | uspto-grants-2012_06 |
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