Acetic Acid → HCID 25213228, compound

Participants

Reaction Steps

Ceric ammonium nitrate (156 mg, 0.189 mmol, 3 eq.) was added to carbamic acid 2-[6-(3-cyano-5-methyl-benzoyl)-5-isopropyl-3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-ethyl ester (32 mg, 0.063 mmol, 1.0 eq.) in a mixture of MeCN (1 mL), acetic acid (0.4 mL) and water (0.2 mL). The reaction mixture was stirred at room temperature for 10 minutes. The reaction mixture concentrated down. Ethyl acetate was added and the mixture was washed with brine. The organic layer was concentrated down and purified (silica gel, 20-80% EtOAc /hexane) to give a white solid (13.6 mg, 56%). 1H NMR (300 MHz, d6 DMSO): δ 11.52 (s, 1H), 8.43 (s, 1H), 8.22 (s, 1H), 8.09 (s, 1H), 3.92 (m, 1H), 3.81 (m, 2H), 3.22 (m, 1H), 2.44 (s, 3H), 2.08 (m, 1H), 1.04 (dd, 6H).

Provenance & Evidence