Potassium Carbonate → HCID 67050492, compound

Participants

Reaction Steps

3-(5-Isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carbonyl)-5-methyl-benzonitrile (Compound 1) (412 mg, 1.386 mmol, 1.0 eq.) was dissolved in 8 mL DMF. Potassium carbonate (191 mg, 1 eq.) was added and the reaction mixture was stirred at room temperature for 10 minutes. 4-Bromo-but-2-enoic acid ethyl ester (0.24 mL, 1 eq.) and lithium iodide (186 mg, 1 eq.) were added. The reaction mixture was stirred at room temperature overnight. Ethyl acetate was added to the reaction mixture, followed by washing with brine. The organic layer was concentrated down and purified (silica gel, 0-80% EtOAC/hexane) to give a light yellow foam (384 mg, 68%). LC-MS shows 410.4 (M+1).

Provenance & Evidence