Ammonium Hydroxide → HCID 67050566, compound

Participants

Reaction Conditions

Reaction Steps

In a 5 mL microwave reaction tube, 4-[6-(3-cyano-5-methyl-benzoyl)-5-isopropyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-but-2-enoic acid ethyl ester (69 mg, 0.168 mmol) and 0.5 mL MeOH was added, followed by 0.7 mL NH4OH (30% in water, excess). The reaction mixture was heated in the microwave at 120° C. for 30 minutes. The reaction mixture concentrated down and purified by reverse phase prep HPLC (MeCN/water) to give a white powder (4.2 mg, 6.6%). 1H NMR (300 MHz, CD3OD): δ 8.8 (d, 1H), 7.64 (m, 2H), 7.4-7.28 (m, 2H), 3.19 (dd, 1H), 2.52 (m, 1H), 0.95 (d, 3H), 0.65 (dd, 3H). LC-MS shows 381.0 (M+1).

Provenance & Evidence