Acetyl bromide → HCID 58203527, compound

Participants

Reaction Conditions

Reaction Steps

AcBr (3 mL) was added to 6-methyl-1-(5-isopropyl-2,6-dimethoxy-pyrimidin-4-yl)-1H-indole-4-carbonitrile (470 mg, 1.40 mmol). The reaction mixture was heated at 70° C. for 6 hours. The reaction mixture was then cooled to room temperature and concentrated. The crude reaction product was purified (silica gel, 0-80% EtOAc/hexane) to give a white solid (280 mg, 65%). LC-MS shows 307.1 (M−1).

Provenance & Evidence