Benzimidazole → HCID 25215200, compound

HRID 2194780Notes

Reaction equation

HRID 2194780 reaction equation
Cl[C:2]1[CH:3]=[C:4]([C:24]#[N:25])C2C=[CH:7][N:8]([C:11]3[N:12]([CH2:22][CH3:23])[C:13](=[O:21])[NH:14][C:15](=[O:20])[C:16]=3[CH:17]([CH3:19])[CH3:18])[C:9]=2[CH:10]=1.N1C2C=CC=CC=2NC=1>>[N:8]1([C:11]2[N:12]([CH2:22][CH3:23])[C:13](=[O:21])[NH:14][C:15](=[O:20])[C:16]=2[CH:17]([CH3:19])[CH3:18])[C:9]2[CH:10]=[CH:2][CH:3]=[CH:4][C:24]=2[N:25]=[CH:7]1

Participants

3

Reactant 2

HCID 5798BenzimidazoleHCID 67050527HCID 67050527, compound

Product 1

HCID 25215200HCID 25215200, compound

Procedure

This compound was made by a procedure similar to that used to prepare 6-chloro-1-(3-ethyl-5-isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-1H-indole-4-carbonitrile (90), except that benzoimidazole was used instead of 6-chloro-1H-indole-4-carbonitrile. LC-MS shows 299.1 (M+1). 1H NMR (300 MHz, CDCl3): δ 9.32 (br, 1H), 7.97 (m, 2H), 7.43 (m, 2H), 7.30 (m, 1H), 3.60 (m, 1H), 3.20 (m, 1H), 1.98 (m, 1H), 1.10 (m, 9H).

Sources & evidence

ORD record
ord-a63bc9dd00dd46f489d5f8f9bdaf98d5
Source dataset
uspto-grants-2012_12
Patent number
US08334295B2

Reaction notes

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