(3S)-3-methylmorpholine → HCID 25254223, compound

Participants

Reaction Steps

Example 8a (74 mg, 0.16 mmol) was reacted with (S)-3-methylmorpholine (3.0 eq.) as described under General Procedure G and the crude mixture was purified by flash chromatography (silica gel, hexane/Et2O 1:4) to afford the title compound as a pale yellow oil (51 mg, 65%). 1H NMR (300 MHz, CDCl3) δ 7.20-7.15 (m, 2H), 7.01-6.95 (m, 2H), 4.05 (t, J=6.0 Hz, 2H), 3.95 (t, J=6.6 Hz, 2H), 3.83 (s, 3H), 3.79-3.57 (m, 4H), 3.22 (dd, J=8.7, 11.1 Hz, 1H), 3.12-2.88 (m, 2H), 2.74 (m, 1H), 2.55-2.35 (m, 6H), 2.18 (s, 3H), 2.07-1.96 (m, 2H), 1.29 (d, J=6.9 Hz, 3H), 0.96 (d, J=6.0 Hz, 3H). MS (ES+) m/z 508.2 (M+H+).

Provenance & Evidence