Iodoethane → HCID 58203459, compound

Participants

Reaction Steps

To a mixture of Compound 98 (0.067 g, 0.202 mmol) and potassium carbonate (0.0279 g, 0.202 mmol) in DMF (1.0 mL) was added iodoethane (14 μL, 0.168 mmol) and reaction mixture was stirred overnight at room temperature. The reaction mixture was quenched with saturated ammonium chloride solution and extracted with ethyl acetate, dried (MgSO4) and concentrated. The resulting residue was purified by reverse phase HPLC (Phenomenex Synergi® column, 5 to 100% acetonitrile/H2O) to give a white powder after lyophilization (20.5 mg, 28%). 1H NMR (300 MHz, CD3CN): 9.15 (s, 1H), 8.16 (s, 1H), 7.96 (s, 1H), 3.52 (br s, 2H), 2.47 (s, 3H), 2.3-2.2 (m, 1H), 1.1-1.0 (s, 9H); Mass Spectrum: 360.2, 362.2 (M+H).

Provenance & Evidence