Acetyl bromide → HCID 21303242, compound

Participants

Reaction Steps

(3,5-Dimethyl-phenyl)-(5-ethyl-2,6-dimethoxy-pyrimidin-4-yl)-amine (5 g, 17.4 mmol) was refluxed with acetyl bromide (50 mL) for 18 hr. After cooling to room temperature, the mixture was evaporated in vacuo and the residue was purified by silica gel column chromatography (eluent, ethyl acetate:hexane (2:1)) to afford 4.5 g (86%) of a white solid. m.p. 238-239° C.; 1H-NMR (200 MHz, CDCl3) δ 0.93 (3H, t, J=7.5 Hz), 2.05-2.15 (3H, m), 2.24-2.40 (8H, m), 6.94-6.99 (3H, m); m/z (EI) 301(M+).

Provenance & Evidence