HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → Methyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1-(4-Fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid | HCID 2912652 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate | HCID 2969493 | — |
Reaction Steps
To 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid 51 was added 80 mL of CH2Cl2, 30 mL of MeOH, and 1.0 mL of concentrated H2SO4. After heating at reflux overnight, the mixture concentrated and triturated with water to give methyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate 52.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08334317B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-2cc664b3ae924667a33cba9c70007ba2 |
| Source note | uspto-grants-2012_12 |