huagongshe.com
HRID2194853

反应详情

EQUATION

反应方程式

HRID 2194853 的结构方程式

REACTANTS

反应物

2
结构：O=P(O)(O)O
HCID1004

Phosphoric acid

H3O4P

结构：CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1
HCID65028

Oseltamivir

C16H28N2O4

PRODUCTS

生成物

1
结构：CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1.O=P(O)(O)O
HCID78000

Oseltamivir phosphate

C16H31N2O8P

PROCEDURE

实验过程

Form B may be formed by adding (3R,4R,5S)-4-acetylamino-5-amino-3-(1-ethyl-propoxy)-cyclohex-1-enecarboxylic acid ethyl ester to the phosphoric acid and cooling the supersaturated solution from 50° C. to −40° C. as fast as possible (without seeding).

WORKUP

后处理

  1. customForm B may be formed
  2. temperaturecooling the supersaturated solution from 50° C. to −40° C. as fast as possible (without seeding)