Diisobutylaluminum hydride → HCID 66717571, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the ester from Step 1 (1 eq.) in THF (0.07M) at −78° C. was added dropwise DIBAL-H (2.1 eq). The reaction mixture was stirred 1 h at −78° C., warm slowly to 0° C. quenched with aqueous 1N HCl and finally diluted with Et2O. The organic extract was washed with aqueous 6N HCl, water, saturated aqueous NaHCO3, brine, dried over MgSO4 filtered and concentrated. Purification by column chromatography on silica gel (Combi-Flash by ISCO), eluting with Hex/EtOAc (0 to 50%, in 30 min) afforded the desired compound.

Provenance & Evidence