2-(2-Methoxyethyl)phenylboronic acid → Tert-butyl {3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-2-[2'-(2-methoxyethyl)-3-methylbiphenyl-4-yl]propyl}carbamate

HRID 2194886Notes

Reaction equation

HRID 2194886 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1B(O)O.Br[C:15]1[CH:20]=[CH:19][C:18]([CH:21]([CH2:31][C:32]2[CH:37]=[CH:36][C:35]([O:38][CH2:39][CH2:40][O:41][C:42]3[C:47]([Cl:48])=[CH:46][C:45]([CH3:49])=[CH:44][C:43]=3[Cl:50])=[CH:34][CH:33]=2)[CH2:22][NH:23][C:24](=[O:30])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[C:17]([CH3:51])[CH:16]=1>>[Cl:48][C:47]1[CH:46]=[C:45]([CH3:49])[CH:44]=[C:43]([Cl:50])[C:42]=1[O:41][CH2:40][CH2:39][O:38][C:35]1[CH:36]=[CH:37][C:32]([CH2:31][CH:21]([C:18]2[CH:19]=[CH:20][C:15]([C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[CH2:4][CH2:3][O:2][CH3:1])=[CH:16][C:17]=2[CH3:51])[CH2:22][NH:23][C:24](=[O:30])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 674459962-(2-Methoxyethyl)phenylboronic acidHCID 86658849Tert-butyl (2-(4-bromo-2-methylphenyl)-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}propyl)carbamate

Product 1

HCID 86658850Tert-butyl {3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-2-[2'-(2-methoxyethyl)-3-methylbiphenyl-4-yl]propyl}carbamate

Procedure

Prepared according to the procedure described in EXAMPLE 1, step 1 using [2-(2-methoxyethyl)phenyl]boronic acid from step 3 and tert-butyl (2-(4-bromo-2-methylphenyl)-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}propyl)carbamate from step 2 as starting materials.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-5bb1b7c6571846e1bc023d8e1caed8b1
Source dataset
uspto-grants-2012_12
Patent number
US08334308B2

Reaction notes

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