HRID2194886

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67445996

未命名化合物

结构：Cc1cc(Cl)c(OCCOc2ccc(CC(CNC(=O)OC(C)(C)C)c3ccc(Br)cc3C)cc2)c(Cl)c1

HCID86658849

未命名化合物

PRODUCTS

生成物

结构：COCCc1ccccc1-c1ccc(C(CNC(=O)OC(C)(C)C)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c(C)c1

HCID86658850

未命名化合物

PROCEDURE

实验过程

Prepared according to the procedure described in EXAMPLE 1, step 1 using [2-(2-methoxyethyl)phenyl]boronic acid from step 3 and tert-butyl (2-(4-bromo-2-methylphenyl)-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}propyl)carbamate from step 2 as starting materials.

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5bb1b7c6571846e1bc023d8e1caed8b1
来源数据集: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08334308B2
来源说明: uspto-grants-2012_12

反应 SMILES

[CH3:1][O:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1B(O)O.Br[C:15]1[CH:20]=[CH:19][C:18]([CH:21]([CH2:31][C:32]2[CH:37]=[CH:36][C:35]([O:38][CH2:39][CH2:40][O:41][C:42]3[C:47]([Cl:48])=[CH:46][C:45]([CH3:49])=[CH:44][C:43]=3[Cl:50])=[CH:34][CH:33]=2)[CH2:22][NH:23][C:24](=[O:30])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[C:17]([CH3:51])[CH:16]=1>>[Cl:48][C:47]1[CH:46]=[C:45]([CH3:49])[CH:44]=[C:43]([Cl:50])[C:42]=1[O:41][CH2:40][CH2:39][O:38][C:35]1[CH:36]=[CH:37][C:32]([CH2:31][CH:21]([C:18]2[CH:19]=[CH:20][C:15]([C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[CH2:4][CH2:3][O:2][CH3:1])=[CH:16][C:17]=2[CH3:51])[CH2:22][NH:23][C:24](=[O:30])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[CH:33][CH:34]=1