HRID2194888

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58083347

未命名化合物

结构：Cc1cc(Cl)c(OCCOc2ccc(CC(CNC(=O)OC(C)(C)C)c3ccc(Br)cc3C)cc2)c(Cl)c1

HCID86658849

未命名化合物

PRODUCTS

生成物

结构：COCCCc1ccccc1-c1ccc(C(CNC(=O)OC(C)(C)C)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c(C)c1

HCID86658851

未命名化合物

PROCEDURE

实验过程

Prepared according to the procedure described in EXAMPLE 1, step 1 using [2-(3-methoxypropyl)phenyl]boronic acid from step 1 and tert-butyl (2-(4-bromo-2-methylphenyl)-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}propyl)carbamate from EXAMPLE 2, step 2 as starting materials.

WORKUP

后处理

customPrepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-73cdf26fea59459c9bcf03caf7ca4bc6
来源数据集: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08334308B2
来源说明: uspto-grants-2012_12

反应 SMILES

[CH3:1][O:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1B(O)O.Br[C:16]1[CH:21]=[CH:20][C:19]([CH:22]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([O:39][CH2:40][CH2:41][O:42][C:43]3[C:48]([Cl:49])=[CH:47][C:46]([CH3:50])=[CH:45][C:44]=3[Cl:51])=[CH:35][CH:34]=2)[CH2:23][NH:24][C:25](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[C:18]([CH3:52])[CH:17]=1>>[Cl:49][C:48]1[CH:47]=[C:46]([CH3:50])[CH:45]=[C:44]([Cl:51])[C:43]=1[O:42][CH2:41][CH2:40][O:39][C:36]1[CH:37]=[CH:38][C:33]([CH2:32][CH:22]([C:19]2[CH:20]=[CH:21][C:16]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=3[CH2:5][CH2:4][CH2:3][O:2][CH3:1])=[CH:17][C:18]=2[CH3:52])[CH2:23][NH:24][C:25](=[O:31])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])=[CH:34][CH:35]=1