[2-(3-Methoxypropyl)phenyl]boronic acid → Tert-butyl {3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-2-[2'-(3-methoxypropyl)-3-methylbiphenyl-4-yl]propyl}carbamate

HRID 2194888Notes

Reaction equation

HRID 2194888 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1B(O)O.Br[C:16]1[CH:21]=[CH:20][C:19]([CH:22]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([O:39][CH2:40][CH2:41][O:42][C:43]3[C:48]([Cl:49])=[CH:47][C:46]([CH3:50])=[CH:45][C:44]=3[Cl:51])=[CH:35][CH:34]=2)[CH2:23][NH:24][C:25](=[O:31])[O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[C:18]([CH3:52])[CH:17]=1>>[Cl:49][C:48]1[CH:47]=[C:46]([CH3:50])[CH:45]=[C:44]([Cl:51])[C:43]=1[O:42][CH2:41][CH2:40][O:39][C:36]1[CH:37]=[CH:38][C:33]([CH2:32][CH:22]([C:19]2[CH:20]=[CH:21][C:16]([C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=3[CH2:5][CH2:4][CH2:3][O:2][CH3:1])=[CH:17][C:18]=2[CH3:52])[CH2:23][NH:24][C:25](=[O:31])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])=[CH:34][CH:35]=1

Participants

3

Reactant 2

HCID 58083347[2-(3-Methoxypropyl)phenyl]boronic acidHCID 86658849Tert-butyl (2-(4-bromo-2-methylphenyl)-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}propyl)carbamate

Product 1

HCID 86658851Tert-butyl {3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-2-[2'-(3-methoxypropyl)-3-methylbiphenyl-4-yl]propyl}carbamate

Procedure

Prepared according to the procedure described in EXAMPLE 1, step 1 using [2-(3-methoxypropyl)phenyl]boronic acid from step 1 and tert-butyl (2-(4-bromo-2-methylphenyl)-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}propyl)carbamate from EXAMPLE 2, step 2 as starting materials.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-73cdf26fea59459c9bcf03caf7ca4bc6
Source dataset
uspto-grants-2012_12
Patent number
US08334308B2

Reaction notes

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