Benzeneacetonitrile, 4-bromo- → 2-(4-Bromophenyl)-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}propanenitrile

HRID 2194889Notes

Reaction equation

HRID 2194889 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][CH:3]=1.[Cl:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[C:14]([Cl:19])[C:13]=1[O:20][CH2:21][CH2:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30]Br)=[CH:26][CH:25]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:30][C:27]2[CH:28]=[CH:29][C:24]([O:23][CH2:22][CH2:21][O:20][C:13]3[C:14]([Cl:19])=[CH:15][C:16]([CH3:18])=[CH:17][C:12]=3[Cl:11])=[CH:25][CH:26]=2)[C:9]#[N:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27914Benzeneacetonitrile, 4-bromo-HCID 584884381,3-Dichloro-2-{2-[4-(bromomethyl)phenoxy]ethoxy}-5-methylbenzene

Product 1

HCID 674491012-(4-Bromophenyl)-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}propanenitrile

Procedure

Prepared according to the procedure described in EXAMPLE 1, step 4 using commercially available (4-bromophenyl)acetonitrile and 1,3-dichloro-2-{2-[4-(bromomethyl)phenoxy]ethoxy}-5-methylbenzene (II.2) as starting materials. Purification by column chromatography on silica gel, eluting with Hex/EtOAc 15%, afforded the desired compound as a colorless oil.

Workup

  1. customPrepared
  2. customPurification by column chromatography on silica gel
  3. washeluting with Hex/EtOAc 15%

Sources & evidence

ORD record
ord-876fb6d7ac6a42ee8c308d356e88b853
Source dataset
uspto-grants-2012_12
Patent number
US08334308B2

Reaction notes

Loading…