HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Bromo-2-fluorophenyl)acetonitrile → 2-(4-Bromo-2-fluorophenyl)-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]-phenyl}propanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Bromo-2-fluorophenyl)acetonitrile | HCID 7172308 | — |
| Reactant | 1,3-Dichloro-2-{2-[4-(iodomethyl)phenoxy]ethoxy}-5-methylbenzene | HCID 58488443 | — |
| Product | 2-(4-Bromo-2-fluorophenyl)-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]-phenyl}propanenitrile | HCID 67445695 | — |
Reaction Steps
Prepared according to the procedure described in EXAMPLE 1, step 4 using commercially available (4-bromo-2-fluorophenyl)acetonitrile and 1,3-dichloro-2-{2-[4-(iodomethyl)phenoxy]ethoxy}-5-methylbenzene (II.1) as starting materials. Purification by column chromatography on silica gel, eluting with Hex/Tol 50%, afforded the desired compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08334308B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-e9556a7a27214386905cb807165acf05 |
| Source note | uspto-grants-2012_12 |