Methyl 3-(2-bromophenyl)propanoate → HCID 67446442, compound

Participants

Reaction Steps

Prepared according to the procedure described in EXAMPLE 1, step 1 using tert-butyl {3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-2-[2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propyl}carbamate from step 1 and commercially available methyl 3-(2-bromophenyl)propanoate as starting materials. Purification by column chromatography on silica gel (Combi-Flash by ISCO), eluting with Hex/EtOAc (10 to 50% in 30 min) afforded the desired compound as a foam.

Provenance & Evidence