HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 6-chloro-4-(trifluoromethyl)nicotinate → Methyl 6-[2-(3-methoxypropyl)phenyl]-4-(trifluoromethyl)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 6-chloro-4-(trifluoromethyl)nicotinate | HCID 2775340 | — |
| Reactant | [2-(3-Methoxypropyl)phenyl]boronic acid | HCID 58083347 | — |
| Product | Methyl 6-[2-(3-methoxypropyl)phenyl]-4-(trifluoromethyl)nicotinate | HCID 67447798 | — |
Reaction Steps
Prepared according to the procedure described in EXAMPLE 1, step 1 using commercially available methyl 6-chloro-4-(trifluoromethyl)nicotinate and [2-(3-methoxypropyl)phenyl]boronic acid from EXAMPLE 3, step 1 as starting materials. Purification by column chromatography on silica gel, eluting with Hex/EtOAc 10% afforded the desired compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08334308B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-e4e773325327491593c8435d9b953102 |
| Source note | uspto-grants-2012_12 |