HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2194898Generated: November 1, 2026
Carbon tetrabromide → 5-(Bromomethyl)-2-[2-(3-methoxypropyl)phenyl]-4-(trifluoromethyl)pyridine
https://huagongshe.com/reaction/2194898
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Carbon tetrabromide | HCID 11205 | — |
| Reactant | 1,2-Bis(diphenylphosphino)ethane | HCID 74267 | — |
| Reactant | [6-[2-(3-Methoxypropyl)phenyl]-4-(trifluoromethyl)pyridin-3-yl]methanol | HCID 67448255 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-(Bromomethyl)-2-[2-(3-methoxypropyl)phenyl]-4-(trifluoromethyl)pyridine | HCID 67444618 | — |
Reaction Steps
To a solution of [6-[2-(3-methoxypropyl)phenyl]-4-(trifluoromethyl)pyridin-3-yl]methanol (1 eq.) from step 2, in CH2Cl2 (0.1M) at 0° C. was added 1-2 bis(diphenylphosphine)ethane (1 eq.) the CBr4 (1 eq.). The mixture was stirred at 0° C. for 45 min, diluted with Hex/EtOAc 10%, filtered in celite and concentrated afforded the desired compound as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08334308B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-dcddd9629eb840f9b766eb5790692cff |
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| Source note | uspto-grants-2012_12 |
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