HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Cyanide → [6-[2-(3-Methoxypropyl)phenyl]-4-(trifluoromethyl)pyridin-3-yl]acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | Methyl 6-[2-(3-methoxypropyl)phenyl]-4-(trifluoromethyl)nicotinate | HCID 67447798 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [6-[2-(3-Methoxypropyl)phenyl]-4-(trifluoromethyl)pyridin-3-yl]acetonitrile | HCID 67446419 | — |
Reaction Steps
A mixture of 5-(bromomethyl)-2-[2-(3-methoxypropyl)phenyl]-4-(trifluoromethyl)pyridine (1 eq.) from step 1 and KCN (5 eq.) in MeOH (0.08M) was stirred for 48 h at room temperature. The mixture was concentrated and purification by column chromatography on silica gel, eluting with Hex/EtOAc 30%, afforded the title desired material as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08334308B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-87896958987448449dcdd864a49dd2b8 |
| Source note | uspto-grants-2012_12 |