反应详情

温度

50 °C

The Venlafaxine Resin Complex was prepared by first dissolving 500 g of venlafaxine HCl in 5 L of purified water, and then slowly adding 1,000 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 25%. EUDRAGIT™ NE-30D polymer of 467 g was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was dried in a 50° C. VWR™ convection oven to the moisture content around 4-6%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

1. additionslowly adding 1,000 g of AMBERLITE™
2. additionThe dispersion was mixed for 4 hours and upon completion
3. custombefore decanting the supernatant
4. customThe wet resin complex was then dried in a VWR™ convection oven
5. additionEUDRAGIT™ NE-30D polymer of 467 g was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
6. customto form a uniform mass
7. customThe wet mass was dried in a 50° C
8. customThe dried granules were then milled through a 40 mesh screen