HRID2194902

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58083347

未命名化合物

结构：Cc1cc(Cl)c(OCCOc2ccc(CC(C#N)c3ccc(Br)cc3C(F)(F)F)cc2)c(Cl)c1

HCID86658853

未命名化合物

PRODUCTS

生成物

结构：COCCCc1ccccc1-c1ccc(C(C#N)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)c(C(F)(F)F)c1

HCID67447413

未命名化合物

PROCEDURE

实验过程

Prepared according to the procedure described in EXAMPLE 7, step 2 using 2-[4-bromo-2-(trifluoromethyl)phenyl]-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}propanenitrile from step 1 and [2-(3-methoxypropyl)phenyl]boronic acid from EXAMPLE 3, step 1 as starting materials. Purification by column chromatography on silica gel (Combi-Flash by ISCO), eluting with Hex/EtOAc (5 to 10%, in 30 min) afforded the desired compound as a colorless oil.

WORKUP

后处理

customPrepared
customPurification by column chromatography on silica gel (Combi-Flash by ISCO)
washeluting with Hex/EtOAc (5 to 10%, in 30 min)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1f82e39967824ca4b7c46d17c57e4593
来源数据集: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08334308B2
来源说明: uspto-grants-2012_12

反应 SMILES

Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][O:21][C:22]3[C:27]([Cl:28])=[CH:26][C:25]([CH3:29])=[CH:24][C:23]=3[Cl:30])=[CH:14][CH:13]=2)[C:9]#[N:10])=[C:4]([C:31]([F:34])([F:33])[F:32])[CH:3]=1.[CH3:35][O:36][CH2:37][CH2:38][CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=1B(O)O>>[Cl:30][C:23]1[CH:24]=[C:25]([CH3:29])[CH:26]=[C:27]([Cl:28])[C:22]=1[O:21][CH2:20][CH2:19][O:18][C:15]1[CH:16]=[CH:17][C:12]([CH2:11][CH:8]([C:5]2[CH:6]=[CH:7][C:2]([C:45]3[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=3[CH2:39][CH2:38][CH2:37][O:36][CH3:35])=[CH:3][C:4]=2[C:31]([F:34])([F:33])[F:32])[C:9]#[N:10])=[CH:13][CH:14]=1