m-Chloroperbenzoic acid → HCID 123948265, compound

Participants

Reaction Steps

To a solution of tert-butyl (3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}-2-{4-[2-(3-methoxypropyl)pyridin-3-yl]-2-methylphenyl}propyl)carbamate (1 eq.) from EXAMPLE 16, step 1 in CH2Cl2 (0.03M) at room temperature was added m-chloroperoxybenzoic acid (1.1 eq.). The reaction mixture was stirred for 3 h at room temperature, poured in saturated aqueous NaHCO3 and extracted with EtOAc. The organic extract was washed with saturated aqueous NaHCO3, brine, dried over Na2SO4, filtered and concentrated. Purification by column chromatography on silica gel, eluting with CH2Cl2/MeOH 5%, afforded the title compound as a foam

Provenance & Evidence