HRID2194910

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58083347

未命名化合物

结构：COC(=O)c1cc(C(C#N)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)ccc1Br

HCID67447431

未命名化合物

PRODUCTS

生成物

结构：COCCCc1ccccc1-c1ccc(C(C#N)Cc2ccc(OCCOc3c(Cl)cc(C)cc3Cl)cc2)cc1C(=O)OC

HCID67448729

未命名化合物

PROCEDURE

实验过程

Prepared according to the procedure described in EXAMPLE 7, step 2 using methyl 2-bromo-5-(1-cyano-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}ethyl)benzoate from step 3 and [2-(3-methoxypropyl)phenyl]boronic acid from EXAMPLE 3, step 1 as starting materials. Purification by column chromatography on silica gel, eluting with Hex/EtOAc (5 then 10%) afforded the desired compound as a colorless oil.

WORKUP

后处理

customPrepared
customPurification by column chromatography on silica gel
washeluting with Hex/EtOAc (5

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4bd7a4bc831042afa035b7ee42a32b04
来源数据集: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08334308B2
来源说明: uspto-grants-2012_12

反应 SMILES

Br[C:2]1[CH:11]=[CH:10][C:9]([CH:12]([C:33]#[N:34])[CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][O:23][C:24]3[C:29]([Cl:30])=[CH:28][C:27]([CH3:31])=[CH:26][C:25]=3[Cl:32])=[CH:16][CH:15]=2)=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[CH3:35][O:36][CH2:37][CH2:38][CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=1B(O)O>>[C:33]([CH:12]([C:9]1[CH:8]=[C:3]([C:4]([O:6][CH3:7])=[O:5])[C:2]([C:45]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[CH2:39][CH2:38][CH2:37][O:36][CH3:35])=[CH:11][CH:10]=1)[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][O:23][C:24]2[C:29]([Cl:30])=[CH:28][C:27]([CH3:31])=[CH:26][C:25]=2[Cl:32])=[CH:16][CH:15]=1)#[N:34]