Hydrochloric Acid → HCID 67444623, compound

Participants

Reaction Steps

Prepared according to the procedure described in EXAMPLE 2, step 5 using tert-butyl (2-{2′-[(acetylamino)ethyl]-3-methylbiphenyl-4-yl}-3-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]phenyl}propyl)carbamate from step 1 as starting materials. Following flash chromatography the desired material (colorless oil) was dissolved in CH2Cl2/Et2O (1/1). HCl (4M in dioxane) was added in excess and the resulting suspension was triturated with Et2O to afford after filtration the title compounds as an off white salt. 1H NMR (500 MHz, CD3OD): δ 7.46 (d, 1H), 7.32-7.25 (m, 4H), 7.20-7.18 (m, 3H), 7.06 (s, 1H), 7.00 (d, 2H), 6.82 (d, 2H), 4.35-4.31 (m, 4H), 3.57-3.52 (m, 1H), 3.42-3.32 (m, 2H), 3.17 (d, 1H), 3.16 (d, 1H), 3.02 (dd, 1H), 2.88 (dd, 1H), 2.84-2.78 (m, 2H), 2.30 (s, 3H), 2.14 (s, 3H), 1.85 (s, 3H).

Provenance & Evidence