Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 5-Pyrimidinecarboxylic acid, 2-[(2-methyl-5-nitrophenyl)amino]-4-(3-pyridinyl)-, ethyl ester | HCID 59253666 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 59253663 | HCID 59253663 | — |
Reaction Steps
23 g ethyl 2-[(2-methyl-5-nitrophenyl)amino]-4-(3-pyridinyl)pyrimidine-5-carboxylate and 19 g sodium carbonate in a mixture composed by 150 mL water and 150 mL ethanol is suspended. It is refluxed for three hours distilling the ethanol, and compensating with water the volume loss. Once completed the conversion, it is cooled to 50° C. and adjusted to pH 6 with acetic acid. The suspension is filtrated, yielding, upon drying, 20 g of product with HPLC purity of 95% (A %), which is identified through 1H-NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08334381B2 |
|---|
| Source dataset | uspto-grants-2012_12 |
|---|
| ORD ID | ord-233f595da26147b7b38c56ba1a64559e |
|---|
| Source note | uspto-grants-2012_12 |
|---|
