Ammonia → HCID 25262434, compound

HRID 219504Notes

Reaction equation

HRID 219504 reaction equation
C([O:4][CH2:5][CH:6]([NH:12][C:13](=[O:71])[C:14]1[C:19]([I:20])=[C:18]([NH:21][C:22](=[O:28])[CH2:23][O:24]C(=O)C)[C:17]([I:29])=[C:16]([C:30](=[O:69])[NH:31][CH2:32][CH2:33][CH2:34][NH:35][C:36](=[O:68])[C:37]2[C:42]([I:43])=[C:41]([NH:44][C:45](=[O:51])[CH2:46][O:47]C(=O)C)[C:40]([I:52])=[C:39]([C:53](=[O:66])[NH:54][CH:55]([CH2:61][O:62]C(=O)C)[CH2:56][O:57]C(=O)C)[C:38]=2[I:67])[C:15]=1[I:70])[CH2:7][O:8]C(=O)C)(=O)C.O.N>CO>[OH:24][CH2:23][C:22]([NH:21][C:18]1[C:17]([I:29])=[C:16]([C:30]([NH:31][CH2:32][CH2:33][CH2:34][NH:35][C:36](=[O:68])[C:37]2[C:42]([I:43])=[C:41]([NH:44][C:45](=[O:51])[CH2:46][OH:47])[C:40]([I:52])=[C:39]([C:53](=[O:66])[NH:54][CH:55]([CH2:56][OH:57])[CH2:61][OH:62])[C:38]=2[I:67])=[O:69])[C:15]([I:70])=[C:14]([C:19]=1[I:20])[C:13]([NH:12][CH:6]([CH2:7][OH:8])[CH2:5][OH:4])=[O:71])=[O:28]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 962WaterHCID 86644957HCID 86644957, compound

Product 1

HCID 25262434HCID 25262434, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The crude Acetic acid 3-acetoxy-2-[3-{3-[3-(2-acetoxy-1-acetoxymethyl-ethylcarbamoyl)-5-(2-acetoxy-acetylamino)-2,4,6-triiodo-benzoylamino]-propylcarbamoyl}-5-(2-acetoxy-acetylamino)-2,4,6-triiodo-benzoylamino]-propyl ester (1.5 g) was dissolved in methanol (10 ml) and water (10 ml) was added. Concentrated aqueous ammonia (3 ml) was added and the solution stirred at ambient temperature for 18 h. The reaction was evaporated to dryness, the residue dissolved in water and purified by preparative hplc to give the title product as a white solid after freeze drying.

Workup

  1. customThe reaction was evaporated to dryness
  2. dissolutionthe residue dissolved in water
  3. custompurified by preparative hplc

Sources & evidence

ORD record
ord-e781d01c6a2741eba6fc1344fdea8326
Source dataset
uspto-grants-2012_06
Patent number
US08202511B2

Reaction notes

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