HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 4-[6-Chloro 4-(3-chloro-4-fluoro-phenyl)-pyridin-2-yl]-morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 2,6-Dichloro-4-(3-chloro-4-fluoro-phenyl)-pyridine | HCID 57761511 | — |
| Product | 4-[6-Chloro 4-(3-chloro-4-fluoro-phenyl)-pyridin-2-yl]-morpholine | HCID 57761141 | — |
Reaction Steps
Stir a solution of 2,6-dichloro-4-(3-chloro-4-fluoro-phenyl)-pyridine (100 mg) in morpholine (2 mL) 3 h at 80° C., concentrate, partition between H2O and EtOAc, dry over Na2SO4, and concentrate under vacuum. Purify by preparative TLC (3:1 hexanes/EtOAc) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08334382B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-4343d1502b334a6ebf2111f76a48a6ef |
| Source note | uspto-grants-2012_12 |