HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-3-Methylmorpholine → 4-[4-(4-Fluoro-phenyl)-6-(2-methyl-piperazin-1-yl)-pyrimidin-2-yl]-3-methyl-morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-3-Methylmorpholine | HCID 641498 | — |
| Reactant | 4-(4-Fluoro-phenyl)-6-(2-methyl-piperazin-1-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine | HCID 66838863 | — |
| Product | 4-[4-(4-Fluoro-phenyl)-6-(2-methyl-piperazin-1-yl)-pyrimidin-2-yl]-3-methyl-morpholine | HCID 66838893 | — |
Reaction Steps
This compound is prepared using (R)-3-methylmorpholine (WO 02/064096) in a procedure analogous to that used for the preparation of 4-(4-fluoro-phenyl)-6-(2-methyl-piperazin-1-yl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine in Example 2F step 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08334382B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-fae9a48770a249c1a684c396150a1411 |
| Source note | uspto-grants-2012_12 |