HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Methyl 5-nitrosalicylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 5-Nitrosalicylic acid | HCID 7318 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Fluoropyrimidine-2,4-diamine | HCID 255608 | — |
| Product | Methyl 5-nitrosalicylate | HCID 87041 | 77% |
Reaction Steps
In a manner analogous to the preparation of N2,N4-bis(3-methoxy-4-methoxycarbonyl)phenyl)-5-fluoro-2,4-pyrimidinediamine, 2-hydroxy-5-nitrobenzoic acid (1 g, 5.5 mmol), potassium carbonate (3 g, 22 mmol) and iodomethane (1 mL, 16 mmol) gave methyl 2-hydroxy-5-nitrobenzoate (880 mg, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08334296B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-ecc2362be98e4786ba8a6f7a123eba67 |
| Source note | uspto-grants-2012_12 |