反应详情

温度

110 °C

A mixture of 6-bromo-5-hydroxy-1H-indazole (25 g, 117 mmol) in acetic acid anhydride (75 mL) is heated at 110° C. with stirring for 2 hours. After it is cooled, diethyl ether (100 mL) is added. The precipitate is collected by filtration, washed with diethyl ether (30 mL), and dried under vacuum to afford the product (34 g, 98% yield). MS (m/z): 297.0 (M+H).

1. temperatureAfter it is cooled
2. filtrationThe precipitate is collected by filtration
3. washwashed with diethyl ether (30 mL)
4. customdried under vacuum