Bis(2,4,6-trichlorophenyl) propanedioate → Coumarin

Participants

Reaction Conditions

Reaction Steps

A mixture of VB482 (835 mg, 3.0 mmol) and bis(2,4,6-trichlorophenyl) malonate (1389 mg, 3.0 mmol) in dry toluene (9 ml) was heated in a sealed tube at 120° C. for 2 hrs. The resulting suspension was cooled and filtered, the solids were washed with hot hexanes and dried in vacuo to give pure coumarin VB483 (568 mg, 55%).

Provenance & Evidence