HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Piperidinecarboxamide → tert-Butyl (3R)-3-carbamoylpiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Piperidinecarboxamide | HCID 92980 | — |
| Reactant | Tert-butyldicarbonate | HCID 22064466 | — |
| Product | tert-Butyl (3R)-3-carbamoylpiperidine-1-carboxylate | HCID 26343680 | 39% |
Reaction Steps
To the reaction mixture obtained in Example 4, tert-butyl dicarbonate (16.1 g, 1.0 equivalent) was added. The pH of the reaction mixture was kept from 7.0 to 8.0. The reaction mixture was stirred for 3 hours at room temperature to obtain a solution containing (R)-1-(tert-butoxycarbonyl)nipecotamide (6.6 g, yield: 39%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338142B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-46a6892738654177be5e8e5b2eed7f43 |
| Source note | uspto-grants-2012_12 |